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      research Advances In The Molecular Pathogenesis And Targeted Therapy Of Psoriasis

      May 2025 in “Galen Medical Journal”
      Psoriasis affects 2-3% of the global population and involves immune dysregulation, keratinocyte dysfunction, and genetic/epigenetic changes, with comorbidities like psoriatic arthritis and cardiovascular disease. Recent advances using single-cell RNA sequencing and transcriptomics have identified key mechanisms such as GSDME-mediated pyroptosis and IL-23/IL-17 axis activation. Targeted therapies, including IL-17 inhibitors like secukinumab and IL-23 inhibitors like risankizumab, show promise, while novel treatments like hyperforin and Deu@Cal microneedles are in early stages. Challenges include adverse events, treatment resistance, and personalization gaps. Future efforts focus on multi-omics integration and combination therapies to enhance precision medicine in psoriasis management.
      Acne and Acneiform Eruptions

      research Acne and Acneiform Eruptions

      2 citations , January 2011 in “Elsevier eBooks”
      Early treatment of acne is crucial to prevent scarring and psychological effects.
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      community Trust the process my friends is

      in Update  377 upvotes 1 month ago
      OP used oral minoxidil (2.5 mg) and dutasteride (0.5 mg) for 12 months with successful hair regrowth. Consistency in treatment is emphasized, and switching from finasteride to dutasteride is suggested for better results.

      community My Results (3 months on Finasteride)

      in Is this regrowth?  385 upvotes 1 year ago
      A 23-year-old shared positive hair regrowth results after using 1mg of oral Finasteride daily for three months, with no side effects reported. The user hopes to continue without adding Minoxidil, as Finasteride alone has been effective.

      community Breezula phase 3 results said to be released next month

      in Product  28 upvotes 1 year ago
      Breezula's phase 3 results are expected soon, with discussions on the effectiveness of androgen receptor antagonists like spironolactone and the potential of GT20029. Users express skepticism about new treatments and discuss the complexities of male pattern baldness, often relying on finasteride despite its side effects.