Multicentric Reticulohistiocytosis Induced Alopecia: A Clinical Case Report

This case report describes a 52-year-old female diagnosed with multicentric reticulohistiocytosis (MRH), a systemic inflammatory disease characterized by dermatologic and musculoskeletal symptoms. The patient presented with red-brown papules, finger swelling, and muscle pain. A biopsy confirmed MRH, and treatment included prednisone, methotrexate, folic acid, and adalimumab. Subsequently, the patient experienced progressive hair loss on the frontal scalp, with a biopsy revealing a marked decrease in follicular units and histiocyte infiltration. This led to a diagnosis of alopecia secondary to MRH, marking the first reported case of such a condition in the literature.