Mrp3, A Mitogen-Regulated Protein/Proliferin Gene Expressed In Wound Healing And In Hair Follicles

The study demonstrated that Mrp3, a mitogen-regulated protein, was induced in keratinocytes at the wound edge during cutaneous wound healing and appeared in the outer root sheath of hair follicles during the late anagen phase of the hair cycle. In cultured keratinocytes, Mrp3 was specifically induced by keratinocyte growth factor. Transgenic mice experiments showed wound- and hair cycle-induced expression of a transgene controlled by Mrp3 regulatory sequences. These findings suggested that Mrp3 played a role in wound healing and the hair follicle cycle as a growth factor and/or angiogenesis factor.