The Therapeutic Efficacy of Mesenchymal Stem Cells and Their Extracellular Vesicles in the Treatment of Diverse Skin Diseases

August 2025 in “ Frontiers in Immunology ”

Mateusz Matwiejuk, Agnieszka Mikłosz, Hanna Myśliwiec, Adrian Chabowski, Iwona Flisiak

mesenchymal stem cells extracellular vesicles alopecia areata microRNAs bone marrow-derived MSCs T cells B cells immunomodulatory effects MSCs EVs

TLDR Mesenchymal stem cells and their vesicles may effectively treat skin diseases, but more research is needed.

This review highlights the potential of mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) in treating various skin diseases, such as psoriasis, atopic dermatitis, and alopecia areata. MSCs and EVs can modulate immune responses and promote tissue regeneration, with EVs showing promise in reducing symptoms by modulating immune pathways. In alopecia areata, EVs enhanced hair regrowth by downregulating inflammatory markers. Despite their promise, challenges like variability in production, potential immune responses, and low targeting efficiency need addressing. Further research and larger clinical trials are necessary to confirm the safety and efficacy of these therapies.

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research Baricitinib-Loaded EVs Promote Alopecia Areata Mouse Hair Regrowth by Reducing JAK-STAT-Mediated Inflammation and Promoting Hair Follicle Regeneration

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The Therapeutic Efficacy of Mesenchymal Stem Cells and Their Extracellular Vesicles in the Treatment of Diverse Skin Diseases

Research cited in this study

research Baricitinib-Loaded EVs Promote Alopecia Areata Mouse Hair Regrowth by Reducing JAK-STAT-Mediated Inflammation and Promoting Hair Follicle Regeneration

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community New and Interesting HairLoss Studies/Papers/Reviews

community Exosomes - do they work as results look promising?

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Microneedling and aloe vera to recruit stem cells.

community This guy claims stem cells fixed his balding

community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

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