MSC-Derived sEV-Loaded Hyaluronan Hydrogel Promotes Scarless Skin Healing by Immunomodulation in a Large Skin Wound Model

    April 2022 in “ Biomedical Materials ”
    Sen Yang, Huan Jiang, Meng Qian, Guangbo Ji, Yongzhen Wei, Ju He, Hongyan Tian, Qiang Zhao
    TLDR A special gel helps heal skin wounds without scars by calming the immune response.
    The study demonstrated that a biofunctional hydrogel, incorporating mesenchymal stem cell-derived small extracellular vesicles (sEVs) into an injectable hyaluronic acid hydrogel, promoted scarless skin healing in a mouse large skin injury model. This hydrogel facilitated wound healing by modulating immune responses, specifically by driving macrophages towards an anti-inflammatory and anti-fibrotic (M2c) phenotype. This shift inhibited fibroblast activation, which is crucial for preventing fibrotic scar formation. The findings suggested that immune response modulation could be an effective strategy for achieving scarless skin wound healing.
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