TLDR Skin and nail changes are common in patients with blood cancers undergoing chemotherapy, affecting their quality of life.
This observational study, conducted on 172 patients with hematolymphoid neoplasms undergoing chemotherapy, found that 15.6% exhibited skin manifestations related to their malignancy, with 4.6% showing direct malignant cell infiltration. Chemotherapy-induced effects were prevalent, with 46.5% experiencing alopecia, particularly linked to cytarabine and methotrexate, and 47.1% having nail changes. Common non-infectious manifestations included cutaneous hyperpigmentation (31.4%) and xerosis (18.6%). The study emphasized the diagnostic challenges and significant impact on quality of life, advocating for early recognition and a multidisciplinary approach to manage these effects. Limitations included difficulties in histopathological confirmation and drug association due to polypharmacy.
2 citations
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October 2016 Chemotherapy and radiotherapy can cause skin side effects like rashes, hair loss, and nail changes, which are usually managed with conservative treatments.
61 citations
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January 2013 in “Indian Journal of Dermatology, Venereology and Leprology” Hair usually grows back 1-3 months after treatment for anagen effluvium, and children with Loose Anagen Hair Syndrome often improve by adolescence.
103 citations
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December 2011 in “Journal of the American Academy of Dermatology” Chemotherapy often causes temporary hair loss, which is distressing and needs better treatment and support.
53 citations
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May 2001 in “The American journal of the medical sciences” Chemotherapy can cause various skin problems, and recognizing them helps improve patient care.
18 citations
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December 1996 in “Seminars in Cutaneous Medicine and Surgery” Chemotherapy and cytokine therapy can cause various skin reactions, including hair loss and hypersensitivity.
7 citations
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November 2021 in “Anais Brasileiros de Dermatologia” Skin side effects from cancer treatments can lead to changes in therapy and are common, with nail changes being the most frequent.
1 citations
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January 2010 in “Elsevier eBooks” Any drug can cause skin reactions, but antibiotics, NSAIDs, and psychotropic drugs are more common, with some reactions being life-threatening.
2 citations
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October 2016 Chemotherapy and radiotherapy can cause skin side effects like rashes, hair loss, and nail changes, which are usually managed with conservative treatments.
