Combining Multiomics to Analyze the Molecular Mechanism of Hair Follicle Cycle Change in Cashmere Goats from Inner Mongolia

    July 2024 in “ Frontiers in Veterinary Science ”
    Chongyan Zhang, Qing Qin, Zhichen Liu, Yichuan Wang, Mingxi Lan, Dan Zhao, Jingwen Zhang, Zhixin Wang, Jinquan Li, Zhihong Liu, Zhihong Liu, Zhihong Liu
    TLDR Apoptosis and ribosomal proteins are key in hair follicle cycle changes in cashmere goats.
    This study used multi-omics joint analysis to investigate the molecular mechanisms behind hair follicle cycle changes in Inner Mongolian Cashmere goats. It identified 917, 1,187, and 716 proteins specifically expressed during the anagen, catagen, and telogen phases, respectively. Gene ontology (GO) and KEGG enrichment analyses revealed that apoptosis significantly impacts the hair follicle growth cycle, with the ribosomal protein family being central in the protein interaction network. The study highlighted API5 and ribosomal proteins as key players in regulating protein and gene expression, affecting hair follicle apoptosis and resting stages. These findings provide a theoretical basis for further research on hair follicle growth and development in these goats.
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