Multilineage-Differentiating Stress-Enduring Cells Alleviate Atopic Dermatitis-Associated Behaviors in Mice

The study demonstrated that multilineage-differentiating stress-enduring (Muse) cells, derived from human bone marrow mesenchymal stem cells, significantly alleviated atopic dermatitis (AD)-associated behaviors in a mouse model. Muse cells reduced scratching behavior, decreased dermatitis severity, and promoted healing of damaged skin. They suppressed inflammatory factors such as IL-6, IL-17α, and IL-33 in the spinal cord and skin, and exhibited anti-inflammatory effects and enhanced wound healing in vitro. The study involved 3-6 mice per group and suggested that Muse cells could potentially serve as a new therapeutic agent for treating AD by modulating immune responses and reducing inflammation.