Myrtus Communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Implications for Hair Loss and Wound Healing

The study investigates the effects of Myrtus communis leaf extract on gene expressions in human keratinocytes (HaCaT cells), focusing on its potential benefits for hair loss and wound healing. The extract, containing 1255 ppm total phenolic substances, was found to significantly downregulate IL-1α and upregulate VEGF gene expressions in treated cells. These changes suggest that M. communis may contribute to healing effects in non-cicatricial hair loss and chronic wounds, as noted in traditional medicine. Further research is needed to fully understand the mechanisms involved.