Myrtus Communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing

The study investigates the effects of Myrtus communis leaf extract on gene expressions in human keratinocytes, focusing on its potential benefits for hair loss and wound healing. The extract was found to contain 1255 ppm of total phenolic substances. It significantly downregulated IL-1α and upregulated VEGF gene expressions in HaCaT cells, suggesting a modulatory effect that may contribute to its traditional use in treating non-cicatricial hair loss and chronic wounds. These findings highlight the need for further research to fully understand the mechanisms behind these healing effects.