Myrtus Communis Leaf Extract Modulates IL-1α and VEGF Gene Expressions in HaCaT Cells: Probable Implications for Its Beneficial Effects in Hair Loss and Wound Healing

The study explored the impact of Myrtus communis leaf extract on gene expression in HaCaT cells, highlighting its potential benefits for hair loss and wound healing. The extract, rich in phenolic compounds, was found to significantly downregulate the pro-inflammatory gene IL-1α and upregulate the pro-repair gene VEGF, with fold changes of 0.45 and 8.38, respectively. These results suggest that M. communis leaf extract may aid in promoting hair growth and wound healing by modulating inflammation and repair-related gene expressions. Further research is necessary to fully understand the mechanisms and interactions of the extract's components.