N6-Methyladenosine RNA Modification Promotes Keratinocyte Proliferation and Cutaneous Wound Repair Through Regulation of MTOR Stability

This study investigates the role of N6-methyladenosine (m6A) in skin, specifically its impact on keratinocyte proliferation and wound repair. The absence of the m6A methyltransferase METTL3 in keratinocytes impairs their proliferation and delays wound healing in mice. The m6A methyltransferase complex activator, MP3C, enhances growth and aids in wound re-epithelialization. The disruption of m6A in keratinocytes reduces m6A levels in MTOR mRNAs, decreasing their stability and suppressing the mTOR pathway, which is crucial for keratinocyte function. These findings suggest that enhancing m6A levels could be a therapeutic strategy for improving wound healing.