Natural Compounds and Biomimetic Engineering to Influence Fibroblast Behavior in Wound Healing

The review highlights the potential of natural compounds and biomimetic engineering in enhancing wound healing by influencing fibroblast behavior. Natural compounds, particularly botanicals and plant-derived products, have been historically significant in wound healing due to their efficacy and minimal side effects, with 70-80% of the global population relying on them. Research on 23 medicinal seaweed species identified Sargassum illicifolium and Haliimeda opuntin as effective in promoting fibroblast proliferation. Biomimetic engineering, including electrospun nanofibers, mimics the skin's extracellular matrix to regulate fibroblast activity. Advanced drug delivery systems, such as nano-drug delivery systems, improve drug bioavailability and create a moist environment beneficial for healing. Despite these advancements, challenges remain in translating findings to clinical settings, including validation in large animal models and production logistics. Integrating ancient remedies with modern approaches shows promise for effective, scar-free wound healing.