Necrosulfonamide Promotes Hair Growth and Ameliorates DHT-Induced Hair Growth Inhibition

The study investigates the role of Mixed-lineage kinase domain-like pseudokinase (MLKL) in hair growth, particularly in androgenetic alopecia (AGA) patients, and the potential of Necrosulfonamide (NSA) as a treatment. It was found that MLKL expression is elevated in alopecia areas of AGA patients and in the outer root sheath (ORS) cells of mice hair follicles. Knockdown of MLKL or inhibition by NSA promoted hair growth and counteracted dihydrotestosterone (DHT)-induced hair growth inhibition. NSA enhances hair growth by inhibiting MLKL activation, promoting Wnt signaling in dermal papillae cells (DPCs), and fostering ORS cell proliferation. This suggests NSA could be a promising anti-alopecia treatment by targeting MLKL-mediated pathways.