TLDR Neuregulin3 affects cell development in the skin and mammary glands.
The study demonstrated that Neuregulin3 (NRG3) significantly influenced cell fate in the epidermis and mammary gland by regulating epithelial proliferation and development. Using transgenic mouse models, researchers observed that NRG3 altered the expression and activation of ErbB receptors, leading to phenotypic changes such as hyperproliferation, sebaceous differentiation, and abnormal hair follicle structures. The findings suggested that NRG3 promoted epidermal proliferation and differentiation into sebaceous lineages over hair lineage, highlighting its potential as a target for therapeutic strategies in related disorders.
384 citations
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June 2005 in “Genes & development” β-catenin is essential for stem cell activation and proliferation in hair follicles.
387 citations
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November 2003 in “Journal of Investigative Dermatology” The K15 promoter effectively targets stem cells in the hair follicle bulge.
182 citations
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May 2003 in “Development” Myc activation reduces skin stem cells by affecting cell adhesion.
555 citations
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July 2001 in “Genes & Development” Tcf3 and Lef1 are key in deciding skin stem cell roles.
315 citations
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June 2001 in “Nature Genetics” 338 citations
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April 2001 in “Current Biology” c-Myc activation in mouse skin increases sebaceous gland growth and affects hair follicle development.
949 citations
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January 2001 in “Cell” Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
198 citations
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March 1999 in “Journal of Investigative Dermatology” Keratin 15 helps maintain tissue integrity and is reduced in activated keratinocytes.
