Nerve Growth Factor and Burn Wound Healing: Update of Molecular Interactions With Skin Cells

August 2023 in “ Burns ”

Mahmoud El Baassiri, Laura Dosh, Hanine Haidar, Alice Gerges, Silma Baassiri, Angelo Leone, Francesca Rappa, Abdo Jurjus

TLDR Nerve growth factor helps improve healing time and scar quality in burn wounds.

The document discusses the role of Nerve Growth Factor (NGF) in burn wound healing. NGF, a protein belonging to the neurotrophins class, is produced by various cell lines and plays a crucial role in the healing process. The healing process involves three overlapping stages: homeostasis/inflammatory phase, proliferative phase, and remodeling phase. NGF regulates the interaction between all types of skin cells, including the nervous system and immune cells, through complex signaling molecules and pathways. However, overexpression of NGF can lead to fibrotic tissue disorders, while its downregulation can delay wound healing. The therapeutic benefits of NGF have been explored in diabetic patients affected by peripheral neuropathies and in a wide range of other applications. The use of NGF in wound healing, particularly burn wound healing, appears promising.

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