TLDR Niosomal methylene blue gel effectively improves moderate to severe acne.
The study aimed to evaluate the use of methylene blue in a niosomal hydrogel form for photodynamic treatment of acne. Researchers formulated and characterized methylene blue niosomes, examining factors like drug amount, cholesterol: span 60 ratios, and stabilizers. The niosomes were successfully produced using the reversed phase evaporation technique, with 1000 µg of methylene blue being optimal for niosomal preparation. The release of methylene blue followed a Higuchi diffusion mechanism, and its incorporation into a 3% HPMC gel resulted in a feasible release rate. Clinical evaluation of the niosomal gel showed a significant improvement in acne inflammation compared to IPL treatment.
260 citations
,
January 2019 in “Pharmaceutics” Niosomes are a promising, stable, and cost-effective drug delivery system with potential for improved targeting and safety.
128 citations
,
July 2009 in “International Journal of Pharmaceutics” PEVs improve minoxidil skin penetration, increasing hair growth.
268 citations
,
April 2009 in “International Journal of Pharmaceutics” Niosomes improve minoxidil skin delivery for hair loss treatment.
57 citations
,
September 2017 in “Journal of controlled release” Nanocarrier-loaded gels improve drug delivery for cancer, skin conditions, and hair loss.
6 citations
,
February 2023 in “Journal of nanobiotechnology” The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.
122 citations
,
December 2022 in “International Journal of Molecular Sciences” Nanoparticles improve skin treatment but need more research on safety and effectiveness.
24 citations
,
January 2023 in “International Journal of Nanomedicine” Biomembrane-based hydrogels can effectively promote chronic wound healing.
20 citations
,
May 2023 in “Cancer Nanotechnology” The new drug delivery system effectively targets lung cancer cells.
