Nonlethal Junctional Epidermolysis Bullosa in a Dog

    August 2004 in “ Veterinary Dermatology ”
    K. Sakurai, Mitsuhiro Sekiguchi, Yasuyuki Momoi, Atsushi Shimizu, Akira Ishiko, Toshiroh Iwasaki
    TLDR A dog with a hereditary skin condition causing blisters and hair loss survived for a year.
    The document described a case of nonlethal junctional epidermolysis bullosa (JEB) in an 8-month-old female mixed-breed dog, characterized by hair loss, blisters, and scar formation on the face, trunk, and feet. Histopathological analysis showed atrophy of hair follicles and degeneration at the dermo-epidermal junction, with blister formation within the lamina lucida. Immunofluorescence tests indicated normal expression of basement membrane zone proteins, and no autoantibodies were detected, suggesting a hereditary form of JEB. Despite disease progression, the dog survived one year post-onset, and the study was self-funded.
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