Application of a Novel Ingredient Blend Promotes Hair Growth by Modulating Wnt/β-Catenin Signaling, DP Inductivity, and Boosting Elastin Expression in Healthy Human Scalp Hair Follicles Ex Vivo

This study investigates a novel multi-compound Blend for its potential to promote hair growth by enhancing elastin deposition and modulating Wnt/β-catenin signaling in ex vivo human hair follicles. Compared to isopropyl cloprostenate (IPC), the Blend significantly increased elastin deposition in various parts of the hair follicle and prolonged the anagen phase, leading to increased hair shaft elongation and keratinocyte proliferation. The Blend also enhanced dermal papilla inductivity by increasing alkaline phosphatase activity and versican expression. These findings suggest that the Blend may promote hair growth through enhanced elastogenesis and modulation of signaling pathways, warranting further investigation to confirm its clinical efficacy.