Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α-Reductase Inhibitor
October 2010
in “
Bioorganic & Medicinal Chemistry Letters
”
TLDR New hybrid compound found to effectively prevent hair loss.
The paper reports on the discovery of a new hybrid compound that inhibits 5α-reductase, an enzyme involved in hair loss. The compound was found to be a potent inhibitor in low IC50 ranges and has potential as a therapeutic agent for the treatment of BPH. The study compared the inhibitory effects of the compound with finasteride and epristeride and concluded that the hybrid compound provides a novel template for the development of pharmacokinetically improved analogues.
