Optimization of Traditional Herbal Formula for Hair Growth from East Nusa Tenggara Using Orthogonal Stimulus Response Method on Hair Density in Mice (Mus musculus)

December 2025 in “ Bioscientist Jurnal Ilmiah Biologi ”

Maximus M. Taek, Dewi Sinta Megawati, Erlangga Sufi Subiyakto, Zahra Khoirunnisa, Novia Maulina, Faisal Akhmal Muslikh, Burhan Ma’arif

traditional herbal formula East Nusa Tenggara RENTT hair growth Taguchi-Orthogonal Stimulus Response Method antioxidant activity hair density alopecia Ficus benjamina IC₅₀ natural cosmeceutical product phytochemical composition traditional herbal remedy hair loss baldness natural cosmetic product

TLDR The optimized herbal formula from East Nusa Tenggara effectively increased hair growth in mice.

This study optimized a traditional herbal formula from East Nusa Tenggara (RENTT) for hair growth using the Taguchi-Orthogonal Stimulus Response Method, demonstrating significant antioxidant activity and effectiveness in increasing hair density in mice with induced alopecia. The optimal RENTT formula, particularly influenced by Ficus benjamina, showed strong antioxidant properties with an IC₅₀ value of 27.46 ppm and outperformed control groups in hair density, suggesting its potential as a natural cosmeceutical product. Further research is needed to explore its phytochemical composition, safety, and efficacy in humans.

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