Comparing the Effectiveness of Oral Isotretinoin and Cyproterone Compound in Acne Treatment Among Adult Females With Cutaneous Hyperandrogenism: A Prospective Study

January 2024

Smita Rani Samal, Sujeet Kumar Singh, Itismita Sahu, Swadesh Kumar Mohanty

isotretinoin cyproterone compound nodulocystic acne cutaneous hyperandrogenism benzoyl peroxide acne severity index androgen levels Accutane Diane-35 acne hormonal imbalance topical treatment

TLDR Isotretinoin is recommended for acne treatment as it is as effective as cyproterone compound.

This study compared the effectiveness of oral isotretinoin and cyproterone compound in treating nodulocystic acne among 30 adult females with cutaneous hyperandrogenism. Participants were divided into two groups of 15, receiving either cyproterone compound or isotretinoin, along with topical benzoyl peroxide. Results showed no significant difference in acne severity index (ASI) score reduction between the two treatments, with both groups experiencing minor side effects. The study concluded that cyproterone compound is not more effective than isotretinoin, recommending isotretinoin for its established efficacy. Further research is suggested to evaluate these treatments independently of androgen levels.

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