TLDR Human sebaceous glands can grow normally for a week without certain growth factors, and adding estrogen reduces their oil production without affecting cell growth.
The study found that human sebaceous glands maintained in a medium without epidermal growth factor (EGF) and phenol red showed in vivo rates of cell division and lipogenesis, as well as preserved morphology, over a period of 7 days. These conditions could be reversed with the re-addition of EGF and phenol red. The introduction of 600 pM 17β-oestradiol significantly decreased lipogenesis over 7 days without affecting cell division, likely due to abnormal differentiation of sebocytes. Testosterone and dihydrotestosterone, at 1 nM concentrations, did not impact cell division or lipogenesis over the same period. However, 1 μM 13-cis-retinoic acid significantly reduced lipogenesis over 7 days.
94 citations
,
February 1994 in “The journal of investigative dermatology/Journal of investigative dermatology” EGF makes hair follicles grow longer but stops hair production.
114 citations
,
September 1985 in “Journal of Investigative Dermatology”
146 citations
,
January 2004 in “Hormones” Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.
February 2024 in “International journal of molecular sciences” Type 3 Innate Lymphoid Cells help maintain skin health and balance, and are involved in skin diseases and healing.
18 citations
,
February 2024 in “ACS Polymers Au” Silk fibroin shows promise for wound care but faces challenges in becoming widely available.
133 citations
,
July 2020 in “Cells” Creating fully functional artificial skin for chronic wounds is still very challenging.
40 citations
,
November 2021 in “International Journal of Molecular Sciences” Mutant keratins cause inflammation in Epidermolysis Bullosa Simplex, suggesting targeting them could help treat the disorder.
