TLDR Lipid peroxidation worsens skin diseases but may help treat cancer.
Lipid peroxidation (LPO) involves the oxidative degradation of lipids, leading to harmful products like malondialdehyde (MDA) and 4-hydroxynonenal (4-HNE), which contribute to the pathogenesis of skin diseases such as psoriasis, vitiligo, and alopecia by promoting inflammation and oxidative stress. While the role of LPO in other skin conditions like atopic dermatitis and melanoma is less clear, elevated LPO biomarkers correlate with disease severity. LPO may also be beneficial in treating neoplastic diseases, as enhancing LPO could support therapies like photodynamic therapy for melanoma by increasing cytotoxicity against cancer cells.
3 citations
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June 2023 in “Frontiers in medicine” Oxidative stress may contribute to hair loss in alopecia areata and antioxidants could potentially help as a treatment.
14 citations
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January 2020 in “Skin appendage disorders” A shampoo with cannabidiol can significantly reduce scalp inflammation and symptoms in people with mild to moderate psoriasis or seborrheic dermatitis.
50 citations
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May 2019 in “BioFactors” Pollution increases a compound in the skin that can lead to faster aging and more inflammation.
35 citations
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December 2014 in “Clinical and experimental dermatology” Oxidative stress may play a role in causing alopecia areata.
62 citations
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July 2013 in “American Journal of Clinical Dermatology” Alopecia areata patients have higher oxidative stress and lower antioxidant levels.
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May 2022 in “Medicina-lithuania” IMA may indicate oxidative stress in skin and hair disorders, but more research is needed.
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June 2022 in “Research Square (Research Square)” Lipid peroxidation may worsen social behavior issues in autism.
75 citations
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February 2017 in “Aging” SkQ1 antioxidant improved health and lifespan in mice.
January 2025 in “Cellular & Molecular Biology Letters” Eicosanoids are crucial for skin health, and targeting their pathways may help treat skin conditions.
