Evaluation of Ozonated Oil and Centella Asiatica Extract on Excisional Wound Healing in Mice

This study evaluated the effects of ozonated oil (VetOzon) and Centella asiatica extract (Madecassol) on wound healing in BALB/c mice. Both treatments enhanced healing compared to the control, with VetOzon acting as an early-phase inflammatory catalyst and Madecassol promoting advanced re-epithelialization and collagen deposition. By day 14, both treatments achieved complete re-epithelialization, unlike the control. Madecassol showed superior collagen deposition on days 14 and 21, indicating better extracellular matrix synthesis. By day 21, treated wounds showed advanced remodeling and hair follicle regeneration, while control wounds lagged. VetOzon is suitable for chronic or infected wounds, while Madecassol is ideal for regenerative healing in clean wounds.