Therapeutic Potential of Asiaticoside in Wound Healing After Endoscopic Submucosal Dissection

Asiaticoside (AS), derived from Centella asiatica, shows significant potential in enhancing wound healing after endoscopic submucosal dissection (ESD) by promoting mucosal regeneration. AS accelerates healing through anti-inflammatory effects, oxidative stress reduction, and fibrosis inhibition, while also promoting angiogenesis and collagen synthesis. Despite its efficacy in skin wounds, AS's application in gastrointestinal contexts is limited by poor bioavailability. Innovative delivery systems like hydrogels and microneedles could improve localized, sustained release, suggesting a shift from passive acid suppression to active mucosal regeneration in ESD management. Future research should focus on developing endoscope-compatible delivery methods to enhance clinical application and reduce complications.