Therapeutic Potential of Asiaticoside in Wound Healing After Endoscopic Submucosal Dissection

Asiaticoside (AS), derived from Centella asiatica, shows significant promise in enhancing wound healing after endoscopic submucosal dissection (ESD) by modulating inflammation, promoting angiogenesis, and regulating collagen synthesis. It acts through anti-inflammatory, antioxidant, and antifibrotic mechanisms, involving pathways like NF-κB, MAPK, and NLRP3, and offers a sustained therapeutic window crucial for ESD ulcer healing. Despite its efficacy, AS's clinical application is limited by poor bioavailability, prompting research into novel delivery systems such as hydrogels and microneedles to improve localized, sustained release. These advancements could transition treatment from passive acid suppression to active mucosal regeneration, potentially reducing ESD-related complications.