TLDR Targeting the p300/AR axis may help treat polycystic ovary syndrome.
This study identifies a transcriptional axis involving p300, SP1, and BRD4 as a key driver of androgen receptor (AR) hyperactivation in polycystic ovary syndrome (PCOS). In mouse models of PCOS, increased histone acetylation and AR activation were observed, which were significantly reduced by p300 knockout or inhibition. The study found that p300, SP1, and BRD4 bind to acetylated histones at the AR promoter, promoting AR transcription. Inhibition of this axis reduced ovarian fibrosis, suggesting that targeting the p300/AR axis could be a promising therapeutic strategy for PCOS.
2 citations
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January 2023 in “International Journal of Biological Sciences” A specific pathway involving AR, miR-221, and IGF-1 plays a key role in causing common hair loss.
131 citations
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September 2017 in “Molecular and Cellular Endocrinology” The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.
162 citations
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January 2015 in “Trends in Endocrinology and Metabolism” Women with PCOS face higher risks of diabetes and heart disease, and these risks increase with obesity.
991 citations
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January 2011 in “Nature Reviews Endocrinology” The document concludes that PCOS is a complex disorder caused by both genetic and environmental factors, affecting women's health in various ways, and requires personalized treatment.
68 citations
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April 2014 in “Journal of Molecular Endocrinology” The document concludes that targeting the androgen receptor may be a promising breast cancer treatment, especially for certain types.
58 citations
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January 2003 in “Thrombosis and Haemostasis” Testosterone may slow down wound healing and increase inflammation.
October 2023 in “Frontiers in endocrinology” Effective PCOS treatments require targeting specific signaling pathways.
50 citations
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May 2004 in “Journal der Deutschen Dermatologischen Gesellschaft” Estrogens generally inhibit hair growth and improve skin quality, but their exact effects on hair follicles are complex and not fully understood.
224 citations
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February 2013 in “The Journal of clinical investigation/The journal of clinical investigation” ERG increases SOX9, promoting prostate cancer growth and invasion.
