P63 Regulates Satb1 to Control Tissue-Specific Chromatin Remodeling During Development of the Epidermis

The study explored the role of the transcription factor p63 in regulating Satb1 to control chromatin remodeling during epidermal development. It demonstrated that p63 directly influenced Satb1 expression in epidermal progenitor cells, with p63-deficient mice showing reduced Satb1 expression and impaired epidermal morphology. Satb1 was crucial for proper chromatin architecture and gene activation within the epidermal differentiation complex (EDC) locus. The restoration of Satb1 expression partially rescued the epidermal phenotype in p63-deficient mice, highlighting its role in the p63-regulated molecular network. The findings suggested that Satb1 regulated gene expression by establishing tissue-specific chromatin conformations, essential for epidermal differentiation. The study provided insights into the molecular mechanisms of skin development and emphasized the significance of chromatin remodeling in tissue-specific gene expression.