Genome-Wide p63-Target Gene Analyses Reveal TAp63/NRF2-Dependent Oxidative Stress Responses

The study explores the roles of TAp63 and ΔNp63, isoforms of the TP63 gene, in regulating oxidative stress responses and transcriptional programs in epithelial cells. TAp63, in collaboration with NRF2, is crucial for managing oxidative stress and maintaining cellular redox balance, which is important for preventing conditions like insulin resistance and liver steatosis. The absence of TAp63 or NRF2 leads to increased reactive oxygen species (ROS) levels. ΔNp63, on the other hand, influences cell motility and differentiation by interacting with Foxj2 and Foxl1. Both isoforms also regulate cell-cycle control and stress responses through interactions with Stat family members. The findings highlight the distinct and overlapping functions of these isoforms in skin biology and cancer, offering insights into potential therapeutic targets.