Co-Expression of PADI Isoforms During Progenitor Differentiation Enables Functional Diversity
October 2023
in “
Philosophical Transactions of the Royal Society B Biological Sciences
”
TLDR Different PADI isoforms help cells develop diverse functions.
The study explores the co-expression of PADI isoforms during progenitor differentiation, emphasizing their role in functional diversity. It identifies distinct roles for PADI isoforms, such as PADI2α promoting and PADI2β inhibiting oligodendrocyte differentiation, with PADI2β being unstable and modulating PADI2α's effects. In hair follicles, PADI3α and PADI3β are co-expressed, with PADI3β reducing PADI3α's enzymatic activity through heterodimer formation. This research highlights the regulatory mechanisms of PADI isoforms in tissue development and their potential implications for diseases, suggesting that these isoforms contribute to lineage progression and cellular differentiation.
