Parry–Romberg Syndrome: Radioclinical Dissociation in a Paucisymptomatic Form and a Proposed Diagnostic Framework

This case report on Parry–Romberg Syndrome (PRS) highlights a 38-year-old female with the condition, characterized by progressive hemifacial atrophy and subclinical intracranial abnormalities detected via MRI. Despite the absence of significant neurological symptoms, the findings suggest central nervous system involvement can occur in clinically stable cases. The report proposes a diagnostic framework and imaging algorithm to aid early diagnosis and standardize the approach for this rare disorder. PRS predominantly affects females and is associated with autoimmune mechanisms, with imaging playing a crucial role in assessing atrophy and monitoring progression. The need for standardized diagnostic criteria and further research into pathogenesis and treatment efficacy is emphasized.