The Effect of Particle Size on the Deposition of Solid Lipid Nanoparticles in Different Skin Layers: A Histological Study

The study investigated the impact of particle size on the penetration of solid lipid nanoparticles (SLNs) into different skin layers. SLNs of sizes 80 nm, 333 nm, and 971 nm were prepared and applied to rat skin, with penetration observed at intervals up to 24 hours. The findings revealed that SLNs smaller than 100 nm penetrated the deepest and most effectively, primarily through hair follicles. This suggested that selecting the appropriate particle size could significantly influence the effectiveness of dermal drug delivery.