Pathophysiology of Insulin Resistance and Related Skin Diseases ( Review Article)

December 2024 in “ Sohag Medical Journal ”

A Lotfy, doaa gaberabdelbaset, E Ismail, Mary Atef Shokry, Amira Ahmed Genedy

insulin resistance keratinocyte proliferation epidermal structure chronic inflammatory skin diseases acne psoriasis proinflammatory cytokines p38 Mitogen activated protein kinases

Insulin resistance, characterized by decreased sensitivity of insulin-targeting tissues, affects skeletal muscle, liver, and adipose tissue, with muscle accounting for up to 70% of tissue glucose absorption. Insulin is crucial for skin physiology, regulating keratinocyte proliferation and differentiation necessary for epidermal structure development. The condition can be inherited, acquired, or mixed, and is linked to chronic inflammatory skin diseases like acne and psoriasis, where high proinflammatory cytokines activate p38 Mitogen activated protein kinases.

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35 citations , March 2011 in “International Journal of Dermatology”

No true link between AGA and insulin resistance, but coexistence may worsen AGA.