TLDR PDGF isoforms can promote and sustain hair growth.
The study explored the impact of PDGF-AA and PDGF-BB on hair growth in C3H mice, finding that these isoforms effectively induced and maintained the anagen phase of hair follicles, as shown by increased skin thickness and hair follicle activity. The role of PDGF in promoting hair growth was confirmed by the disruption of the anagen phase with anti-PDGF antibodies. Additionally, PDGF treatments upregulated key signaling molecules like Shh, Wnt5a, and Lef-1, suggesting that PDGF isoforms could be potential treatments for alopecia by promoting and sustaining hair growth.
55 citations
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September 2003 in “Experimental Dermatology” PDGF signaling may play a role in hair growth cycle regulation.
60 citations
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April 2003 in “Biomaterials” Controlled release of growth factors in hydrogels improved hair growth in mice.
73 citations
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November 2000 in “Proceedings of the National Academy of Sciences of the United States of America” There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.
231 citations
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October 1999 in “Journal of Clinical Investigation” Activating the Sonic hedgehog gene in mice can start the hair growth phase.
109 citations
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April 1998 in “Journal of Investigative Dermatology” HGF/SF injections can stimulate hair growth and increase hair follicle size in mice.
94 citations
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March 1996 in “Journal of Investigative Dermatology”
2 citations
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January 2022 in “Stem cell biology and regenerative medicine” Extracellular vesicles, including exosomes from certain cells, can stimulate hair growth.
April 2025 in “Diagnostics” Managing inflammation and using vitamins can improve PRP therapy for better hair growth.
January 2012 in “Elsevier eBooks” New treatments for skin and hair repair show promise, but further improvements are needed.
37 citations
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April 2017 in “npj Regenerative Medicine” PDGF signaling is crucial for maintaining and renewing hair follicle stem cells, which could help treat hair loss.
July 2024 in “ADMET & DMPK” Surface-modified nanostructured lipid carriers can improve hair growth treatments.
