PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles

The study explored the impact of PDGF-AA and PDGF-BB on hair growth in C3H mice, finding that these isoforms effectively induced and maintained the anagen phase of hair follicles, as shown by increased skin thickness and hair follicle activity. The role of PDGF in promoting hair growth was confirmed by the disruption of the anagen phase with anti-PDGF antibodies. Additionally, PDGF treatments upregulated key signaling molecules like Shh, Wnt5a, and Lef-1, suggesting that PDGF isoforms could be potential treatments for alopecia by promoting and sustaining hair growth.