The Pivotal Role of PDGF and Its Receptor Isoforms in Adipose-Derived Stem Cells
July 2015
in “
PubMed
”
TLDR PDGF and its receptors are crucial for stem cell growth and function.
The document reviewed the role of platelet-derived growth factor (PDGF) and its receptor isoforms in adipose-derived stem cells (ASCs). It highlighted that ASCs express PDGF-A, -C, -D, PDGFRα, and PDGFRβ, with PDGFRα expression decreasing with adipocyte lineage, while PDGFRβ inhibits white adipocyte differentiation and promotes proliferation, migration, and angiogenesis. PDGF-D, in particular, was noted for its endogenous nature, ability to generate reactive oxygen species (ROS) via the mitochondrial electron transport system, and regulation of the autocrine loop of ASCs in vivo, with stronger mitogenic effects compared to PDGF-B. The review emphasized the distinct roles of PDGF isoforms in ASC regulation and their underlying molecular mechanisms.
