PDGFA in Cashmere Goat: A Motivation for the Hair Follicle Stem Cells to Activate

January 2019 in “ Animals ”

Irene Pazzaglia, Francesca Mercati, Marco Antonini, Stefano Capomaccio, Katia Cappelli, Cecilia Dall’Aglio, Antonietta La Terza, Matteo Mozzicafreddo, Cristina Nocelli, Stefano Pallotti, Dario Pediconi, C. Renieri

TLDR PDGFA helps activate hair growth in cashmere goats.

The study examined the role of Platelet-Derived Growth Factor A (PDGFA) in the hair follicle cycle of cashmere goats, using 7 one-year-old female goats. It found that PDGFA, along with Bone Morphogenetic Protein 2 (BMP2), had higher expression levels during the late catagen and early anagen phases, indicating their involvement in hair follicle growth and activation of hair follicle stem cells. PDGFA was localized in the basal layer of the outer root sheath and showed stronger immunostaining in regressive hair follicles. The research suggested that PDGFA played a significant role in promoting hair growth and could aid in improving cashmere fiber production.

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research Epithelial Expression of the Hormone Leptin by Bovine Skin

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research Whole-Genome Sequencing of Eight Goat Populations for the Detection of Selection Signatures Underlying Production and Adaptive Traits

92 citations , December 2016 in “Scientific Reports”

Researchers identified genes linked to coat color, body size, cashmere production, and high altitude adaptation in goats.

research Hairy Tale of Signaling in Hair Follicle Development and Cycling

161 citations , August 2012 in “Seminars in cell & developmental biology”

Hair growth and development are controlled by specific signaling pathways.

research Effect of IGF-I on Hair Growth Is Related to the Anti-Apoptotic Effect of IGF-I and Up-Regulation of PDGF-A and PDGF-B

72 citations , January 2012 in “Annals of Dermatology”

IGF-I promotes hair growth by keeping hair follicles in the growth phase longer.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations , September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

research Hair Growth Stimulated by Conditioned Medium of Adipose-Derived Stem Cells Is Enhanced by Hypoxia: Evidence of Increased Growth Factor Secretion

134 citations , January 2010 in “Biomedical research”

Low oxygen conditions increase the hair-growing effects of substances from fat-derived stem cells by boosting growth factor release.

research Characterization of BMP2 Gene Expression in Embryonic and Adult Inner Mongolia Cashmere Goat (Capra Hircus) Hair Follicles

18 citations , December 2009 in “Canadian Journal of Animal Science”

The BMP2 gene is more active in the early growth phase of Cashmere goat hair and may affect hair regeneration and textile production.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles

136 citations , June 2006 in “Journal of Dermatological Science”

PDGF isoforms can promote and sustain hair growth.

research Biology of the Hair Follicle: The Basics

224 citations , March 2006 in “Seminars in Cutaneous Medicine and Surgery”

The document concludes that understanding hair follicle biology can lead to better hair loss treatments.

research Regulation of PDGF and PDGF Receptor in Cultured Dermal Papilla Cells and Follicular Keratinocytes of the Human Hair Follicle

55 citations , September 2003 in “Experimental Dermatology”

PDGF signaling may play a role in hair growth cycle regulation.

research Growth Factor and Growth Factor Receptor Localization in the Hair Follicle Bulge and Associated Tissue in Human Fetus

94 citations , March 1996 in “Journal of Investigative Dermatology”

research Growth of Secondary Hair Follicles of the Cashmere Goat In Vitro and Their Response to Prolactin and Melatonin

56 citations , August 1994 in “PubMed”

Prolactin and melatonin can stimulate hair growth in Cashmere goat hair follicles, but melatonin may reduce follicle viability over time.