Peimine Promotes Skin Wound Repair in Mice by Activating the Notch1 Signaling Pathway in Fibroblasts

This study investigated the effects of peimine on skin wound healing in mice, focusing on the Notch1 signaling pathway. Using C57BL/6 mice with surgically created skin defects, peimine was applied topically at doses of 1 and 4 mg/kg. In vitro experiments with NIH/3T3 fibroblasts treated with peimine at 25 and 100 μmol/L concentrations supported these findings. Results showed that peimine significantly improved wound closure rates and granulation tissue formation, increased epidermal thickness, and promoted extracellular matrix remodeling. These effects were linked to the upregulation of Notch1 pathway components, suggesting that peimine enhances wound repair by activating Notch1 signaling.