Pericyte Plasticity in the Brain

Hair growth relies on mechanical forces, not just chemicals, with tissue acting like a motor. Minoxidil and finasteride help, but maintaining tissue elasticity and addressing mechanical issues are essential.

The user tried various hair loss treatments for a year, initially using Hims foam min, Ketoconazole, dermarolling/microneedling, Biotin, Collagen, Caster and rosemary oil, and a multivitamin. From June, they switched to Keeps topical fin and min gel, Ketoconazole, dermarolling/microneedling, collagen, Caster and rosemary oil, and a multivitamin, and noticed hair thickening, especially on the front hairline.

Collagen peptides are recommended for hair and skin benefits, with users noting improvements in hair and skin health. However, evidence on their effectiveness for hair growth is inconclusive.

Aminexil/Kopexil may help reduce hair loss by addressing perifollicular fibrosis in androgenetic alopecia, but it lacks the extensive clinical backing of finasteride and minoxidil. Some users find it effective, but availability and cost are issues, especially in the US where it's not FDA-approved.

The user experiences severe anxiety and physical symptoms after taking finasteride and is seeking alternative hair loss treatments since dutasteride is unavailable. They suspect an allergic reaction to finasteride and have stopped using it.

Hair loss treatments, specifically 5AR inhibitors, can impact neurosteroids and sexual health. The effects of topical fin/dut on tissue-specific DHT levels are unclear.