Derivation of Stem Cell-Like Cells From Spherical Culture of Astrocytes for Enhanced Neural Repair After Middle Cerebral Artery Occlusion

    April 2022 in “ Frontiers in Bioengineering and Biotechnology ”
    Dan Zhu, Zheming Cao, Xiaoyang Pang, Wei Jiang, Chihao Li, Xing Zhang, Xibin Tian, Haijun Tu, Panfeng Wu, Hemin Nie
    TLDR Astrocytes can become stem cell-like and help repair brain damage.
    The study investigated the transformation of mouse astrocytes into stem cell-like cells (A-iSCs) through 3D sphere culture, which enhanced their ability to differentiate into neurons. These A-iSCs were transplanted into a mouse model of middle cerebral artery occlusion, where they improved sensorimotor functions and promoted nerve regeneration by expressing neural differentiation markers and growth factors like BDNF and NGF. The study involved 8 mice per group and demonstrated significant functional recovery, suggesting that A-iSCs could be a promising source for neural regeneration and stroke recovery therapies.
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