Prostaglandin D2 Inhibits Wound-Induced Hair Follicle Neogenesis Through the Receptor Gpr44

    November 2012 in “ Journal of Investigative Dermatology ”
    Amanda E. Nelson, Dorothy E. Loy, John A. Lawson, Adiya S. Katseff, Garret A. FitzGerald, Luis A. Garza
    Image of study
    TLDR Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.
    The study from April 1, 2013, explored the impact of Prostaglandin D2 (PGD2) on the regeneration of hair follicles after skin injury in mice, focusing on the Gpr44 receptor. The researchers discovered that higher levels of PGD2 and its synthase (Ptgds) were associated with reduced hair follicle regeneration during the later stages of wound healing. Conversely, a splice variant of Ptgds lacking exon 3 correlated with increased regeneration. Application of PGD2 to wild-type mice reduced hair follicle neogenesis, while Gpr44-null mice exhibited increased regeneration and resistance to PGD2's inhibitory effects. The study, which included sample sizes ranging from 5 to 31 mice per genotype, suggests that the PGD2-Gpr44 pathway could be a therapeutic target for enhancing skin regeneration and treating hair loss conditions.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 90 results

      community Need supplemental products in addition to oral minoxidil and oral dutasteride

      in Product  1 upvotes 4 months ago
      The user has been using oral minoxidil and dutasteride for hair loss without success and is considering adding topical 17α-estradiol, Pyrilutamide, Clascoterone, or cetirizine. They have confirmed low serum DHT levels and are exploring additional treatments due to genetic sensitivity to DHT and prostaglandin D2.

      community DNA test result is incredible !

      in Technology  30 upvotes 1 week ago
      The conversation discusses a personalized hair loss treatment plan based on DNA test results, recommending Minoxidil, Dutasteride, 17-alpha Estradiol, Cetirizine, and PRP sessions. The test identifies a high risk of hair loss due to DHT but a good response to Minoxidil, suggesting a tailored approach to treatment.

      community You will lose hair if your prostaglandins aren't in balance

      in Research/Science  55 upvotes 10 months ago
      Prostaglandin balance affects hair loss, particularly in conditions like Lichen Planopilaris, where an imbalance can lead to hair follicle damage. Treatments mentioned include prostaglandin analogs and Pioglitazone HCL, with a focus on maintaining prostaglandin equilibrium for potential hair regrowth.

    Related Research

    1 / 1 results