Pharmacokinetic Study in Hairless Rat After Topical Application of Finasteride: Single and Repeated Dose

January 2012 in “ Journal of Investigative Dermatology ”

F. Mailland, Silvia Tampucci, Susi Burgalassi, Patrizia Chetoni, Maurizio Caserini, Daniela Monti

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community [study analysis] Microdose of topical Finasteride for all the benefits and none of the sides?

in Research/Science 104 upvotes 5 years ago

Topical finasteride as a potential alternative to oral finasteride for reducing DHT levels on the scalp with fewer side effects, and other hair loss treatments such as minoxidil.

community If half life of fin is 6-8 hours in the blood but 5-6 days in tissue (scalp) why don't people apply topical every 3-4 days to minimize systemic?

in Treatment 28 upvotes 2 years ago

The discussion revolves around the frequency of applying topical finasteride for hair loss treatment. The main question is whether applying it every 4-5 days could still be effective, given that its half-life in the scalp tissue is 5-6 days.

community Blood results on micro-dosing topical finasteride (DHT Increased!)

in Finasteride/Dutasteride 5 upvotes 3 years ago

The conversation discusses using homemade topical finasteride for hair loss, showing an increase in DHT levels despite treatment. The user applies 0.125mg daily, resulting in 113.4% of previous DHT levels.

community How long is topical Fin “active” on the scalp?

in Finasteride/Dutasteride 6 upvotes 2 years ago

Topical finasteride remains active on the scalp for a certain period after application, and there is concern about the safety of touching the hair and transferring the medication to the fingers.

community Topical finasteride (P-3074) inhibits scalp DHT up to 70%

in Finasteride/Dutasteride 20 upvotes 3 months ago

Topical finasteride (P-3074) can inhibit scalp DHT by up to 70%, with some users experiencing systemic absorption similar to oral use. Users discuss varying application frequencies and concentrations, with some noticing side effects when overused.

community Targeted Follicular Finasteride Delivery: A Low-Systemic Strategy

in Research/Science 14 upvotes 2 months ago

A peptide-based delivery system for finasteride shows promise in reducing systemic side effects while maintaining hair growth effectiveness. Combining this with other treatments like minoxidil and RU58841 could enhance results with lower systemic absorption.