Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

June 2014 in “ Journal of Pharmaceutical Sciences ”

Daniela Monti, Silvia Tampucci, Susi Burgalassi, Patrizia Chetoni, Carla Lenzi, Andrea Pirone, Federico Mailland

finasteride topical formulations cutaneous depot hair bulbs systemic absorption hair loss Propecia

TLDR Finasteride cream helps hair growth with less side effects.

The study evaluated the use of topical formulations containing finasteride for the treatment of hair loss. The selected formulation, P-08-016, was found to promote a high level cutaneous depot of finasteride in the region surrounding the hair bulbs while minimizing systemic absorption, making it a potential alternative to systemic therapy for the treatment of hair loss. Further studies are needed to verify the exact quantity of drug retained inside the hair bulbs.

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Research cited in this study

18 / 18 results

research Alopecia: Evaluation and Treatment

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Liposomes improve finasteride delivery for hair loss treatment, making it a promising option for topical use.

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Liposomes and niosomes improve finasteride delivery for hair loss treatment.

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Minoxidil and finasteride can slow hair loss and stimulate regrowth, but won't restore all lost hair or reverse complete baldness.

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Finasteride effectively treats male pattern baldness, improving hair growth and density.

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Male pattern baldness is largely genetic, linked to the androgen receptor gene, and may relate to certain health issues.

research Minoxidil vs Finasteride in the Treatment of Men With Androgenetic Alopecia

40 citations , September 2003 in “Archives of Dermatology”

Finasteride slightly better long-term, minoxidil faster initial results, but stopping minoxidil may cause hair loss.

research Permeant Lipophilicity and Vehicle Composition Influence Accumulation of Dyes in Hair Follicles of Human Skin

44 citations , April 2003 in “European journal of pharmaceutical sciences”

Lipophilic dyes accumulate more in hair follicles when delivered with surfactant-propylene glycol solutions.

research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

174 citations , November 2002 in “Expert Reviews in Molecular Medicine”

Hair loss needs more research for better treatments.

research The Psychosocial Consequences of Androgenetic Alopecia: A Review of the Research Literature

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Hair loss affects self-esteem and quality of life; treatments can help.

research Finasteride

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Finasteride effectively treats baldness but may cause sexual side effects.

research Male Pattern Hair Loss: Current Understanding

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Genetics and hormones cause hair loss; finasteride treats it safely.

research Topical Finasteride in the Treatment of Androgenic Alopecia: Preliminary Evaluations After a 16-Month Therapy Course

30 citations , January 1997 in “Journal of Dermatological Treatment”

Topical finasteride helps regrow hair and reduce balding without side effects.

research Clinical Pharmacokinetics and Pharmacodynamics of Finasteride

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Finasteride helps regrow hair and shrink prostate by reducing DHT, with some sexual side effects.

research Relative Influence of Ethanol and Propylene Glycol Cosolvents on Deposition of Minoxidil into the Skin

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Ethanol over 50% helps minoxidil absorb better into skin.

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106 citations , June 1990 in “Journal of Investigative Dermatology”

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research Topical Formulations Containing Finasteride: In Vitro Permeation/Penetration Study and In Vivo Pharmacokinetics in Hairless Rat

23 citations , June 2014 in “Journal of Pharmaceutical Sciences”

Finasteride cream helps hair growth with less side effects.