Efficacy of Polyphenolic Compounds for Hair Regeneration: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This systematic review and meta-analysis examined 32 randomized controlled trials involving 2,183 participants to assess the efficacy of polyphenolic compounds for hair regeneration in non-scarring alopecia. The study found that polyphenolic interventions significantly improved hair density and total area hair count compared to controls, with standardized mean differences of 0.90 and 1.03, respectively. Despite substantial heterogeneity among studies, polyphenolic compounds, such as flavonoids, procyanidins, and curcuminoids, show promise as treatments for androgenetic alopecia. Comparisons with minoxidil indicated no significant differences in overall hair count outcomes. The findings suggest polyphenolic formulations could be a potential adjunctive treatment, but further standardized and long-term trials are necessary to confirm these results.