Efficacy of Polyphenolic Compounds for Hair Regeneration: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This systematic review and meta-analysis evaluated the efficacy of polyphenolic compounds for hair regeneration in adults with non-scarring alopecia, analyzing 32 randomized controlled trials with 2,183 participants. The study found that polyphenolic interventions significantly improved hair density and total area hair count compared to controls, although there was substantial heterogeneity in the results. While direct comparisons with minoxidil did not show significant differences in overall hair count outcomes, the findings suggest that polyphenolic formulations could be a potential adjunctive treatment for non-scarring alopecia. However, further standardized and long-term trials are needed to confirm these results.