Efficacy of Polyphenolic Compounds for Hair Regeneration: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

This systematic review and meta-analysis assessed the efficacy of polyphenolic compounds for hair regeneration in adults with non-scarring alopecia, analyzing 32 randomized controlled trials with 2,183 participants. The study found that polyphenolic interventions significantly improved hair density and total area hair count compared to controls, although there was substantial heterogeneity. However, direct comparisons with minoxidil showed no significant differences in overall hair count outcomes. The findings suggest that polyphenolic formulations could be a potential adjunctive treatment for non-scarring alopecia, but further standardized and long-term trials are needed to confirm these results.