(1R,2S)-4-(2-Cyano-Cyclohexyl-Oxy)-2-Trifluoromethyl-Benzonitrile, A Potent Androgen Receptor Antagonist For Stimulating Hair Growth And Reducing Sebum Production

    August 2007 in “ Bioorganic & Medicinal Chemistry Letters ”
    Lain-Yen Hu, Daniel K. Du, Jennifer K. Hoffman, Yvonne E. Smith, Victor Fedij, Catherine R. Kostlan, Theodore M. Johnson, Yun Huang, Steve Kesten, William G. Harter, Wen Yue, Jie Li, Nicole Chantel Barvian, Lorna Helen Mitchell, Huangshu John Lei, Bruce Allen Lefker, Matthew Carroll, Danielle Dettling, Teresa Krieger-Burke, Brian Samas, Radhika Yalamanchili, Kimberly Lapham, David Pocalyko, Drago Robert Sliskovic, Susan Ciotti, Brenda Stoller, Hena Mostafa, Qizhu Ding, Samarendra N. Maiti, Michael Stier, Howard G. Welgus
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    TLDR The compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile can stimulate hair growth and reduce oil production when applied topically.
    In 2007, a study was conducted on the compound (1R,2S)-4-(2-Cyano-cyclohexyl-oxy)-2-trifluoromethyl-benzonitrile, an androgen receptor antagonist, to assess its potential in stimulating hair growth and reducing sebum production. The compound was tested on two animal models: male C3H/HeN mice and male Syrian hamsters, with 10 and 5 animals in each experimental group respectively. The compound was applied topically twice daily for 4 weeks in mice and for 2 weeks in hamsters. The study found that the compound demonstrated significant potency in stimulating hair growth and reducing sebum production. It also showed reversible pharmacology and favorable pharmacokinetic characteristics for a topical agent. However, the results of metabolic stability tests in rat, dog, and human hepatocytes, as well as pharmacokinetics in male Sprague-Dawley rats and transepidermal delivery through human cadaver skin, were not provided in the document.
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