Potential Genetic Associations of Acne Scar Phenotypes: IL1A in Fibrotic Scarring and CYB5R1 in Atrophic Scarring

    April 2026 in “ Biomedical Research and Therapy ”
    Dong-Kha To, Duy-Khang Nguyen, Quynh-Giang Nguyen, Tuan-Khoi Duong, Dang-Khoa Nguyen, Hoang-Dung Nguyen, Chi‐Bao Bui
    Image of study
    TLDR CYB5R1 and IL1A genes may be linked to different types of acne scars.
    This study investigated genetic associations with acne scarring in 202 acne patients, revealing that CYB5R1 variants are potentially linked to atrophic scarring, while IL1A variants are associated with fibrotic scarring, including hypertrophic and keloid scars. No significant associations were found with the other genes studied (TNF, TLR4, FLG, and SPINK5). The findings suggest a polygenic nature of acne scarring, but further research with larger cohorts is needed for validation.
    Discuss this study in the Community →