Predictive Factors for Therapeutic Response and Cluster Analysis in Syndrome of Undifferentiated Recurrent Fever (SURF)

    July 2025 in “ RMD Open ”
    Serena Palmeri, Marta Ponzano, Giada Recchi, Chiara Conti, Saverio La Bella, Diana Sutera, Marta Bustaffa, Caterina Matucci‐Cerinic, Roberta Bertelli, Federica Penco, Ignazia Prigione, Riccardo Papa, Isabella Ceccherini, Stefano Volpi, Roberta Caorsi, Marco Gattorno
    TLDR IL-1 blockade is effective for treating SURF, and personalized treatment is needed.
    The study on the syndrome of undifferentiated recurrent fever (SURF) identifies predictors of resistance to colchicine treatment and supports the effectiveness of IL-1 blockade as a therapeutic approach. Cluster analysis reveals the heterogeneity within SURF, highlighting the necessity for improved diagnostic criteria and personalized treatment strategies.
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