Progesterone in gender-affirming therapy of trans women

The article explored the potential clinical implications of adding bioidentical progesterone to the gender-affirming treatment of trans women. Progesterone was expected to provide moderate anti-androgen effects, aid in breast maturation, and offer long-term benefits such as preventing bone loss and protecting cardiovascular health. These potential benefits were inferred from the hormone's biological actions in cisgender women, and the article emphasized the need for caution and further research to confirm the efficacy and safety of progesterone in hormonal regimens for trans women.