The Role of Prostanoids in Regulatory T Cells and Their Implications in Inflammatory Diseases and Cancers

This document discusses the role of regulatory T cells (Tregs) in maintaining immune system balance and their involvement in tissue repair. Tregs are characterized by the expression of FOXP3, CD25, and CTLA-4. The paper highlights the importance of prostanoids, lipid mediators derived from arachidonic acid, in regulating Treg differentiation and function. Prostanoids act through 9 specific receptors and are crucial in modulating Treg activity, which has implications for inflammatory diseases and cancers. The review summarizes previous research on Treg regulation and recent findings on prostanoids' modulatory roles.