Prostate Cancer Risk And Recurrence: The Role Of Nutrition And Clinical Aspects

This thesis explored the role of nutritional and clinical factors in prostate cancer risk and recurrence. It found that higher total and LDL cholesterol levels were linked to an increased risk of aggressive prostate cancer in a cohort of 2,118 men. Additionally, cancer survivors had a higher risk of prostate cancer within the first year after their initial cancer diagnosis, likely due to active screening. Body mass index (BMI) was not associated with biochemical recurrence risk in patients treated with radical prostatectomy. A selenium intervention trial with 15 participants showed that selenium influenced gene expression towards an anti-inflammatory profile in the prostate. These findings suggested that specific factors might affect prostate cancer risk and gene expression, highlighting the need for further research to develop effective prevention and treatment strategies.