Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway
October 2017
in “
Drug Design Development and Therapy
”
TLDR DA-9401 helps protect rat testis from finasteride damage.
The study investigated the protective effect of DA-9401 on finasteride-induced apoptosis in rat testis. Finasteride caused infertility and apoptosis in testicular tissue, but DA-9401 was found to attenuate these effects. The study suggests that DA-9401 may have a protective effect against finasteride-induced apoptosis in rat testis through the inositol requiring kinase 1 and c-Jun N-terminal kinase pathway. Further studies are needed to understand the interaction between 5α-reductase inhibitors and DA-9401 in the hypothalamic-pituitary-testicular axis in humans.
